{"id":2832,"date":"2021-05-10T17:49:20","date_gmt":"2021-05-10T16:49:20","guid":{"rendered":"https:\/\/cystinosis.ie\/?page_id=2832"},"modified":"2021-05-10T17:49:20","modified_gmt":"2021-05-10T16:49:20","slug":"tjessa-bondue","status":"publish","type":"page","link":"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/","title":{"rendered":"Tjessa Bondue"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_third-1e26125d131ba13f1accaa8241be1528\">\n.flex_column.av-av_one_third-1e26125d131ba13f1accaa8241be1528{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-av_one_third-1e26125d131ba13f1accaa8241be1528 av_one_third  avia-builder-el-0  el_before_av_two_third  avia-builder-el-first  first flex_column_div av-zero-column-padding '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-koiuasww-f9d7e9d4328ce54e27c5696cac6ae4ae\">\n.avia-image-container.av-koiuasww-f9d7e9d4328ce54e27c5696cac6ae4ae img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-koiuasww-f9d7e9d4328ce54e27c5696cac6ae4ae .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-koiuasww-f9d7e9d4328ce54e27c5696cac6ae4ae av-styling- avia-align-center  avia-builder-el-1  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-2833 avia-img-lazy-loading-not-2833 avia_image ' src=\"https:\/\/cystinosis.ie\/wp-content\/uploads\/2021\/05\/Tjessa-Bondue-257x300.png\" alt='Tjessa Bondue photograph' title='Tjessa Bondue'  height=\"300\" width=\"257\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/cystinosis.ie\/wp-content\/uploads\/2021\/05\/Tjessa-Bondue-257x300.png 257w, https:\/\/cystinosis.ie\/wp-content\/uploads\/2021\/05\/Tjessa-Bondue.png 294w\" sizes=\"(max-width: 257px) 100vw, 257px\" \/><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_two_third-da852e3ef3e55b029d2629c41a20524d\">\n.flex_column.av-av_two_third-da852e3ef3e55b029d2629c41a20524d{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-av_two_third-da852e3ef3e55b029d2629c41a20524d av_two_third  avia-builder-el-2  el_after_av_one_third  avia-builder-el-last  flex_column_div av-zero-column-padding '     ><section  class='av_textblock_section av-koiu87me-994eaba9ae88b7ad1b7fd183231579a3'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span data-contrast=\"auto\">Tjessa Bondue is a<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">young and energetic\u00a0<\/span><span data-contrast=\"auto\">newcomer to the field of cystinosis<\/span><span data-contrast=\"auto\">. She only recently graduated as a Master in the Biomedical Sciences from the\u00a0<\/span><span data-contrast=\"auto\">Katholieke<\/span><span data-contrast=\"auto\">\u00a0Universiteit Leuven<\/span><span data-contrast=\"auto\">\u00a0(KU Leuven)<\/span><span data-contrast=\"auto\">\u00a0in 2020<\/span><span data-contrast=\"auto\">. Her first introduction to the subject<\/span><span data-contrast=\"auto\">\u00a0of cystinosis<\/span><span data-contrast=\"auto\">\u00a0was in 2018, when she was able to enjoy a short internship in the Laboratory of P<\/span><span data-contrast=\"auto\">a<\/span><span data-contrast=\"auto\">ediatric Nephrology<\/span><span data-contrast=\"auto\">\u00a0and the cystinosis research<\/span><span data-contrast=\"auto\">\u00a0of Prof. Elena Levtchenko and Prof. Bert van den Heuvel.\u00a0<\/span><span data-contrast=\"auto\">There, she was so intrigued by the disease<\/span><span data-contrast=\"auto\">, which was not known to her before the internship,<\/span><span data-contrast=\"auto\">\u00a0that she decided to pursue the subjec<\/span><span data-contrast=\"auto\">t further\u00a0<\/span><span data-contrast=\"auto\">as\u00a0<\/span><span data-contrast=\"auto\">her<\/span><span data-contrast=\"auto\">\u00a0Master Thesis project<\/span><span data-contrast=\"auto\">\u00a0in 2019 \u2013 2020. Her Thesis,\u00a0<\/span><span data-contrast=\"auto\">about the potential\u00a0<\/span><span data-contrast=\"auto\">and the<\/span><span data-contrast=\"auto\">\u00a0future use of<\/span><span data-contrast=\"auto\">\u00a0<\/span><i><span data-contrast=\"auto\">CTNS<\/span><\/i><span data-contrast=\"auto\">\u00a0mRNA-based therapeutics to treat cystinosis<\/span><span data-contrast=\"auto\">, introduced her to the world of RNA-based therapeutics<\/span><span data-contrast=\"auto\">.<\/span><span data-contrast=\"auto\">\u00a0During this time, she was\u00a0<\/span><span data-contrast=\"auto\">also\u00a0<\/span><span data-contrast=\"auto\">fully introduced in the laboratory and was able to attend several conferences and patient meetings, further cementing her fascination with the disease and\u00a0<\/span><span data-contrast=\"auto\">allowing her to fully realize\u00a0<\/span><span data-contrast=\"auto\">how\u00a0<\/span><span data-contrast=\"auto\">cystinosis\u00a0<\/span><span data-contrast=\"auto\">affected the patients<\/span><span data-contrast=\"auto\">\u00a0and<\/span><span data-contrast=\"auto\">\u00a0<\/span><span data-contrast=\"auto\">the need for a new therapeutic strategy to help these people.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">While the thesis project itself was<\/span><span data-contrast=\"auto\">\u00a0cut short due to the Covid-19 crisis, a good base was laid down for the future research in this topic.\u00a0<\/span><span data-contrast=\"auto\">While the world of mRNA-based therapeutics was still in its early stages before the Covid-19 crisis, with two siRNA-based therapeutics being approved in 2018 and 2019, the research domain was revolutionized and introduced to the wider public with the quick development of the mRNA-based vaccines for SARS-CoV2.\u00a0<\/span><span data-contrast=\"auto\">\u00a0This led Tjessa to fully realize the future potential of the mRNA-based approach for the future treatment of patients suffering from a variety of diseases. Therefore, she did\u00a0<\/span><span data-contrast=\"auto\">not want to\u00a0<\/span><span data-contrast=\"auto\">let go of\u00a0<\/span><span data-contrast=\"auto\">het Master thesis<\/span><span data-contrast=\"auto\">\u00a0project<\/span><span data-contrast=\"auto\">\u00a0and<\/span><span data-contrast=\"auto\">\u00a0decided to pursue\u00a0<\/span><span data-contrast=\"auto\">the<\/span><span data-contrast=\"auto\">\u00a0subject further<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In 2020, she<\/span><span data-contrast=\"auto\">\u00a0wrote and<\/span><span data-contrast=\"auto\">\u00a0defended\u00a0<\/span><span data-contrast=\"auto\">th<\/span><span data-contrast=\"auto\">e subject of mRNA-based therapy for cystinosis in\u00a0<\/span><span data-contrast=\"auto\">front of the jury of the Research Foundation Flanders (FWO) and was amongst the lucky ones to obtain the FWO-fellowship<\/span><span data-contrast=\"auto\">\u00a0and continue the journey as a PhD-project<\/span><span data-contrast=\"auto\">.\u00a0<\/span><span data-contrast=\"auto\">Currently, she is a first year PhD student in the laboratory of Prof. Elena Levtchenko and Prof. Bert van den Heuvel, trying to further advance this potential new therapeutic strategy, by establishing the potential of CTNS mRNA to ameliorate the cystinosis phenotype, with the\u00a0<\/span><span data-contrast=\"auto\">main focus<\/span><span data-contrast=\"auto\">\u00a0being the kidney.<\/span><\/p>\n<\/div><\/section><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":2660,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tjessa Bondue - Cystinosis Ireland<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tjessa Bondue - Cystinosis Ireland\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/\" \/>\n<meta property=\"og:site_name\" content=\"Cystinosis Ireland\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cystinosis.ie\/wp-content\/uploads\/2019\/07\/Cystinosis-Ireland-New.png\" \/>\n\t<meta property=\"og:image:width\" content=\"340\" \/>\n\t<meta property=\"og:image:height\" content=\"156\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/\",\"url\":\"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/\",\"name\":\"Tjessa Bondue - Cystinosis Ireland\",\"isPartOf\":{\"@id\":\"https:\/\/cystinosis.ie\/#website\"},\"datePublished\":\"2021-05-10T16:49:20+00:00\",\"dateModified\":\"2021-05-10T16:49:20+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/cystinosis.ie\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Home\",\"item\":\"https:\/\/cystinosis.ie\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research\",\"item\":\"https:\/\/cystinosis.ie\/home\/research\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"8th Annual Dublin Cystinosis Workshop\",\"item\":\"https:\/\/cystinosis.ie\/?page_id=2097\"},{\"@type\":\"ListItem\",\"position\":5,\"name\":\"Dublin Cystinosis Workshop 2021 &#8211; Agenda\",\"item\":\"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/\"},{\"@type\":\"ListItem\",\"position\":6,\"name\":\"Tjessa Bondue\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cystinosis.ie\/#website\",\"url\":\"https:\/\/cystinosis.ie\/\",\"name\":\"Cystinosis Ireland\",\"description\":\"Research. Awareness. Support.\",\"publisher\":{\"@id\":\"https:\/\/cystinosis.ie\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cystinosis.ie\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/cystinosis.ie\/#organization\",\"name\":\"Cystinosis Ireland\",\"url\":\"https:\/\/cystinosis.ie\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/cystinosis.ie\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cystinosis.ie\/wp-content\/uploads\/2019\/07\/Cystinosis-Ireland-New.png\",\"contentUrl\":\"https:\/\/cystinosis.ie\/wp-content\/uploads\/2019\/07\/Cystinosis-Ireland-New.png\",\"width\":340,\"height\":156,\"caption\":\"Cystinosis Ireland\"},\"image\":{\"@id\":\"https:\/\/cystinosis.ie\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tjessa Bondue - Cystinosis Ireland","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/","og_locale":"en_GB","og_type":"article","og_title":"Tjessa Bondue - Cystinosis Ireland","og_url":"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/","og_site_name":"Cystinosis Ireland","og_image":[{"width":340,"height":156,"url":"https:\/\/cystinosis.ie\/wp-content\/uploads\/2019\/07\/Cystinosis-Ireland-New.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimated reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/","url":"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/","name":"Tjessa Bondue - Cystinosis Ireland","isPartOf":{"@id":"https:\/\/cystinosis.ie\/#website"},"datePublished":"2021-05-10T16:49:20+00:00","dateModified":"2021-05-10T16:49:20+00:00","breadcrumb":{"@id":"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/tjessa-bondue\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/cystinosis.ie\/"},{"@type":"ListItem","position":2,"name":"Home","item":"https:\/\/cystinosis.ie\/"},{"@type":"ListItem","position":3,"name":"Research","item":"https:\/\/cystinosis.ie\/home\/research\/"},{"@type":"ListItem","position":4,"name":"8th Annual Dublin Cystinosis Workshop","item":"https:\/\/cystinosis.ie\/?page_id=2097"},{"@type":"ListItem","position":5,"name":"Dublin Cystinosis Workshop 2021 &#8211; Agenda","item":"https:\/\/cystinosis.ie\/home\/research\/dublin-cystinosis-workshop\/dublin-cystinosis-workshop-2021-agenda\/"},{"@type":"ListItem","position":6,"name":"Tjessa Bondue"}]},{"@type":"WebSite","@id":"https:\/\/cystinosis.ie\/#website","url":"https:\/\/cystinosis.ie\/","name":"Cystinosis Ireland","description":"Research. Awareness. Support.","publisher":{"@id":"https:\/\/cystinosis.ie\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cystinosis.ie\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/cystinosis.ie\/#organization","name":"Cystinosis Ireland","url":"https:\/\/cystinosis.ie\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/cystinosis.ie\/#\/schema\/logo\/image\/","url":"https:\/\/cystinosis.ie\/wp-content\/uploads\/2019\/07\/Cystinosis-Ireland-New.png","contentUrl":"https:\/\/cystinosis.ie\/wp-content\/uploads\/2019\/07\/Cystinosis-Ireland-New.png","width":340,"height":156,"caption":"Cystinosis Ireland"},"image":{"@id":"https:\/\/cystinosis.ie\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/pages\/2832"}],"collection":[{"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/comments?post=2832"}],"version-history":[{"count":1,"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/pages\/2832\/revisions"}],"predecessor-version":[{"id":3108,"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/pages\/2832\/revisions\/3108"}],"up":[{"embeddable":true,"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/pages\/2660"}],"wp:attachment":[{"href":"https:\/\/cystinosis.ie\/wp-json\/wp\/v2\/media?parent=2832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}